A very good nuclear positivity.
Too strong.
Needs further dilution
However, there is a lower level of cytoplasmic positivity.
Not really a problem, imho.
Unlike several other species, BACE1 is present in exocrine acini ( lumenal aspect). It is also seen in a subset of Islet of Langerhans cells ( mostly peripheral).
This is a PM pancreas so, levels of intensity may be diminished.
A new batch of this ab ( thanks, Book!) is very good.
Hippocampal Dentate gyrus region shown.
Svz region ( exit zone) of Lateral ventricle. A new batch of this Ab is very good.
SVZ of Lateral ventricle showing developing /progenitor olfactory bulb interneurons.
Exit zone of RMS of new olfactory interneurons – Left to right direction ( lateral ventricle).
A new batch is excellent.
A slight b’ground positivity in OB but, no problem.
Progenitor olfactory interneurons dispersing throughout the OB.
A new batch of this Ab reagent gives a cleaner, more sensitive positivity in mouse and rat compared with my original batch ( 2014)
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