Surprisingly, the positivity is very clear ( excellent signal:noise)

Similar to pig.

A very good nuclear positivity.

Too strong.

Needs further dilution

However, there is a lower level of cytoplasmic positivity.

Not really a problem, imho.

Unlike several other species, BACE1 is present in exocrine acini ( lumenal aspect). It is also seen in a subset of Islet of Langerhans cells ( mostly peripheral).

This is a PM pancreas so, levels of intensity may be diminished.