Positivity is, imho, the same as in mouse brain.

However, I would appreciate comments from anyone who knows about this protein and it’s distribution pattern.

Astrocytes are positive. Note that the capillary in L/S is delineated.There is a punctate “background” positivity…? astrocyte processes?

Upper image shows punctate positivity in C. putamen. Lower image of small intestine shows punctate positivity of nerve fibres within Auerbach’s and Meissner’s plexusues and individual fibres throughout the muscularis and the lamina propria. Additionally, there are occasional cells within the epithelium of the mucosa that are intensely positive ( cytoplasm). These cells appear to have the orientation of neuroendocrine cells.

Note that there is punctate positivity in  nerve fibres within Auerbach’s plexuses and also in individual nerve fibres within the smooth muscle.

Note that there is punctate positivity in  nerve fibres within Auerbach’s plexuses and also in individual nerve fibres within the smooth muscle.

An older patient who thus,  most sadly, hadn’t been diagnosed.  So,  a massive proliferation of compensatory nerve fibres that are useless?

A functional technique, determining that the macrophages are activated. Immunomethods using anti CD68/Ox42….would be the modern equivalent?