Amyloid can be obscure. Re: congo red
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From: | "J. A. Kiernan" <jkiernan@julian.uwo.ca> (by way of histonet) |
To: | histonet <histonet@magicnet.net> |
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On Fri, 9 Oct 1998, Bryan Llewellyn wrote:
> I have run into this on a few occasions. It is in the nature of amyloid to
> be variable in staining. If you really must prove its presence, then cut
> some of the tissue out of the block, dewax it and send it for EM. Although
> the ultrastructural morphology will be the pits, the very characteristic
> structure of amyloid is retained. We did this on a case a few years ago,
> when the only stain that demonstrated it was thioflavin T. It did turn out
> to be amyloid.
Bryan Llewellyn
This is a real HistoNet gem!
John Kiernan
London, further E. in Canada.
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