I'll bet 5 bucks it goes back to your fixative - what type are you using? 
We experienced this problem when using  zinc based fixatives with GI 
biopsies, and reverted back to plain old 10% NBF.

Jackie O'




"Michele Becker" 
Sent by: histonet-bounces@lists.utsouthwestern.edu
10/06/2004 03:21 PM

 
        To:     "Histonet" 
        cc: 
        Subject:        [Histonet] GI bx


Please help....................  We are having problems with blurring and
distorted nuclei on some of our GI biopsies. This has been happening on 
and
off for the past few months.  It is not every day and not all the GI bx on
any given day. We have ruled out staining and processing. I really think 
it
is something happening to the bxs before we even receive them but want to
make sure we have not left any stones unturned on our end first.  Any
suggestions?

Thank-you.

Michele



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