Dr. Miyagishima,
The bromo and fluoro-modified nucleotides have been used to do kinetic
studies. There are mAb which can distinguish between these two halogenated
nucleotides (IU3 and IU4 I think, originally developed by a group in
California system). For instance, you can inject the Br derivative into a
patient, then after some treatment, inject the  fluoronated nucleoside
and... after a lag period, tumor biopsies can be differentially stained to
indicate the effectiveness of the therapy on S-phase index. Again, my memory
of names fails me; but , I believe a woman at Rush in Chicago has published
some of this work several years ago.
Ty Lee


-----Original Message-----
From: Masayuki Miyagishima, MD <mmiyagis+@pitt.edu>
To: Histonet@Pathology.swmed.edu <Histonet@Pathology.swmed.edu>
Date: Monday, April 05, 1999 10:45 PM
Subject: BrdU and FrdU


>In some literature, they are injecting both BrdU and FrdU.  Do we need
>this FrdU?
>--
>Masayuki Miyagishima, MD
>University of Pittsburgh,
>Department of Surgery
>412-647-2345, and ask the hospital operator to page 3228, please.
>
>